2025 Year in Review
Built on Legacy.
Wired for the Future.
For 25 years, Cleveland Clinic Innovations has been turning
insights into solutions that improve patients’ lives.
Born out of a vision to bring the discoveries of our renowned scientists, researchers and clinicians to the world, we’ve evolved into a commercialization partner that matches each opportunity with the right model, the right partners and the right capital. We’re building a future where transformative breakthroughs reach patients faster—powered by Cleveland Clinic’s world-class reputation and innovative healthcare ecosystem that combines clinical expertise, research capabilities and commercialization infrastructure.
A Letter from the Chief of Cleveland Clinic Innovations
2025 has been a defining year for Cleveland Clinic Innovations, demonstrating how far we’ve come in building a comprehensive, integrated innovation engine with global reach.
Our “team of teams” guides technologies from initial conversations through proof of concept, development and deal execution, and the results speak for themselves. Startups in our portfolio are securing regulatory clearances and raising significant funding. We’re working with strategic partners who share our vision for solving healthcare’s greatest unmet needs—and they’re validating, refining and generating evidence alongside Cleveland Clinic clinicians in ways that reduce risk and accelerate time to market. Partners have a clear, reliable framework for collaboration.
In 2025, we saw artificial intelligence make the leap from pilot projects to patient impact. We’ve deployed clinically validated AI in high stakes areas including oncology, where treatments are limited, and in sepsis detection and care, where accuracy and speed directly affect outcomes.
The London Innovation Hub was introduced to our ecosystem this year, further expanding our global footprint. Our collaborations with Khosla Ventures and other investors work in both directions, creating connections between innovators, clinical expertise and capital across North America, Europe and the Middle East.
As we look toward 2026, we remain committed to targeting healthcare challenges and diseases with the greatest unmet need. I’m grateful for our deeply experienced Innovations team and the researchers, clinicians, inventors and strategic partners who make our work possible.
Innovation Impact
2025 Highlights
We’ve shifted from a traditional tech transfer office to a comprehensive, integrated innovation engine — one that is global, faster, and more aligned with how healthcare needs to innovate today.
Geoff Vince, PhD
Chief, Cleveland Clinic Innovations
Chair, Biomedical Engineering
An Evolving Approach to
How We Innovate
We call ourselves the innovation powerhouse because we are doing more than just tech transfer work.
—Saqib Sachani, PhD, MBA,
Director, Innovations Business Development
We are expanding the ways we bring innovations to patients at scale.
Ways to Work With Us
Inbound Innovation
Enterprise Business Development
Co-Development
Caregiver ideas that solve unmet needs
An Ecosystem Primed for Innovation and Impact
Partnerships With Economic Impact
We’re building an ecosystem alongside partners so that cutting-edge healthcare technology and ideas can be developed here in Ohio and then refined and used worldwide.
Advancing Discovery from Bench to Bedside
Here, discovery happens across specialties and across the globe. Our transformative research facilities connect clinicians, researchers, data scientists and other caregivers as they address local problems while creating a global impact—priming the ecosystem for innovation alongside key partners.
Accelerating Breakthroughs through Capital and Commercialization
Moving innovations from concept to market requires the right combination of capital and resources. We support promising technologies at critical stages of development and commercialization.
Cultivating the Next Generation of Talent and Ideas
We’re passionate about transforming caregiver ideas into life-changing products, which is why we foster innovation opportunities and curate inventor resources for our 82,000+ caregivers.
Artificial Intelligence and Precision Medicine Where It Matters Most
...We emphasize both the importance of AI to our strategic vision and the urgency of practical applications that can benefit our clinicians and patients today.
—Rohit Chandra, PhD
Executive Vice President & Chief Digital Officer, Cleveland Clinic
This year, we deployed clinically validated AI to target diseases with the greatest unmet need.
Sepsis care and detection, where accuracy and speed directly affect outcomes.
Oncology, opening doors to predict patient responses to treatments when options are limited.
Neurology, transforming brain wave monitoring from an hours-long manual review process to detecting changes in the brain’s electrical activity within seconds.
We're also tackling operational challenges like identifying patients for clinical trials and using ambient listening to reduce caregiver burnout.
Our clinical expertise, data infrastructure and implementation capabilities allow AI to move from proof-of-concept into standard practice, positioning Cleveland Clinic as a de-risking partner for collaborators who share our goals of solving healthcare’s greatest unmet needs.
As we test and implement new technology, we remain deliberate and uncompromising in our commitment to patient safety.
Cleveland Clinic Innovations
Global Expansion
Innovation Without Borders
Innovations backed by the world’s #2 hospital and deployed across a global healthcare system
Cleveland Clinic’s global infrastructure provides the reach needed for clinical validation at scale. With operations spanning three continents, strategic collaborators may have the opportunity to validate, refine and generate evidence in diverse patient populations and varied regulatory environments.
In 2025, Cleveland Clinic Innovations engaged in notable international collaborations:
In 25 years, we’ve evolved from a medical-device-focused operation into a balanced, global innovation engine advancing therapeutics, digital health, and AI.
—Geoff Vince, PhD
Chief, Cleveland Clinic Innovations
Chair, Biomedical Engineering
25 Year Innovation Engine
From Medical Devices to Artificial Intelligence: 25 Years of Cleveland Clinic Innovations
When Cleveland Clinic Innovations began in 2000, our body of work centered largely on medical devices and inventions targeting specific diagnoses and conditions. Today, our medical device portfolio remains strong, yet we’ve shifted into a new era that reimagines the whole health journey through innovation. We’ve expanded to include digital health, therapeutics and diagnostics. We’re developing and commercializing technologies that streamline hospital operations and reduce costs, accelerate treatments and target patients for specific interventions.
It goes back to people, processes and systems. Our team-of-teams model includes separate groups for sourcing ideas, assessing them, developing them, and handling licensing deals. Each group has different skill sets, so we can optimize performance at each stage. We have processes that track technology development, and we use a lean, outcomes-driven approach. We stay focused on what matters most: improving outcomes and operational efficiencies.
—Geoff Vince, PhD
Cleveland Clinic Innovations
Our Operating Model
The Future of Healthcare Since 1921
Long before Cleveland Clinic Innovations was officially established as the hospital’s commercialization partner, Cleveland Clinic has been a place for innovation and medical breakthroughs. Since its founding, innovations that started here have changed medicine:
Discovery of serotonin, a neurotransmitter that affects body and mood (1948)
Pioneering “stopped heart” surgery (1956) and coronary artery bypass surgery (1967)
Development of coronary angiography to reveal artery blockages (1958)
Discovery of a brain-mapping technique to pinpoint epileptic seizures (1980)
Leading-edge left atrial appendage device introduced (2006)*
First U.S. near-total face transplant performed (2008)*
First deep brain stimulation for stroke recovery performed (2017)*
Development of a vaccine to prevent deadly triple-negative breast cancer (2021)*
* indicates Cleveland Clinic Innovations milestone
25 Years of Results
2,800+
patents issued
950+
licenses
108
29
portfolio companies
monetized
Innovations Insights and Perspectives
We’re looking for ways to improve care, optimize operations, or enhance patient experience. If we can do all of those, even better.
—JD Friedland, MBA
Executive Director, Innovations Investments and Ventures
A Year Defined by Innovation and Impact
In 2025, Cleveland Clinic Innovations demonstrated what’s possible when clinical expertise, data and the right partnerships come together, from artificial intelligence being deployed in high-stakes care environments to portfolio companies advancing through regulatory milestones and funding rounds.
As we look ahead, our focus remains clear: accelerating innovation that improves patients’ lives and shapes the future of healthcare.
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